Neutralizing Antibody Responses After mRNA COVID-19 Booster Vaccination are Unaffected by Parasitemia in a Malaria-Endemic Setting

  1. Taraz Samandari
  2. Millicent Achola
  3. Jack N. Hutter
  4. Grace Mboya
  5. Walter Otieno
  6. Jia Jin Kee
  7. Yunda Huang
  8. John J. Aponte
  9. Christian F. Ockenhouse
  10. Cynthia K. Lee
  11. Laura Polakowski
  12. Margaret Yacovone
  13. Asa Tapley
  14. Sufia Dadabhai
  15. Nonhlanhla N. Mkhize
  16. Haajira Kaldine
  17. Sinethemba Bhebhe
  18. Penny L. Moore
  19. John Hural
  20. Nigel Garrett
  21. James G. Kublin
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Abstract

Subclinical malaria may reduce the immunogenicity of mRNA vaccines. We evaluated neutralizing antibody responses in adults with (n=87) and without (n=221) PCR-confirmed Plasmodium falciparum who received a COVID-19 booster. Similar boosted ID50 geometric mean titers >22,000 in parasitemic and non-parasitemic participants suggests that COVID-19 mRNA vaccine responses are not impaired.

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  1. Version published to 10.1101/2025.04.12.25325718v1 on medRxiv