Easydecon: A Lightweight Workflow for Cell Type Analysis in High-Definition Spatial Transcriptomics Assays
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Spatial transcriptomics enables mapping gene expression within tissue structures. The VisiumHD platform by 10x Genomics advances this further, offering near-single-cell resolution across tissue sections. Here we introduce Easydecon, a lightweight bioinformatics workflow leveraging similarity algorithms and regression-based cell type proportion estimation to transfer cell types and deconvolute spatial bins. Easydecon streamlines visualization and spatial deconvolution by utilizing differentially expressed genes identified from single-cell RNA sequencing datasets.
