Association of reduced estimated GFR with mortality in men and women across the adult age spectrum in the Optum Labs Data Warehouse

Chronic kidney disease (CKD) is associated with multiple adverse outcomes. This study quantifies the mortality risk associated with CKD, characterized by an estimated glomerular filtration rate (eGFR) of <60 ml/min/1.73m ² , utilizing de-identified electronic health record data from the Optum Labs Data Warehouse in 4,788,021 men and 5,766,551 women. Mortality rates were estimated per 1000 person-years by sex and 5-year age group and absolute risk difference were estimated as attributable risk per 1000 person-years. Elevated mortality rates were seen among individuals with reduced eGFR for all age groups and for both men and women. The analysis revealed a linear decline in the incidence rate ratios of mortality with advancing age, while attributable risks increased due to the marked increase in mortality with age. These sex-specific risk estimates from a large sample enhance previous findings and are crucial for refining global burden of disease metrics and health economic evaluations of CKD.