A Multicenter, Controlled, Randomized Trial of Home-Applied Dual-Light Photodynamic Therapy in Chronic Periodontitis

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Abstract

Aim

This multicenter, randomized controlled trial evaluated the efficacy of the Lumoral® dual-light antibacterial photodynamic (aPDT) home care device as an adjunct tool to non-surgical periodontal treatment (NSPT) in chronic periodontitis patients.

Materials and Methods

Forty-one Stage I-III periodontitis patients were randomized to receive NSPT, including standardized hygiene instructions and scaling and root planing, or NSPT with adjunctive Lumoral® treatment, applied daily at home. Clinical examinations were conducted at baseline, three months, and six months.

Results

Both groups showed significant reductions in Visual Plaque Index (VPI) and Bleeding on Probing (BOP) at three and six months. However, the NSPT + Lumoral® group exhibited significantly greater BOP and VPI reductions at six months (p=0.03, p=0.04) compared to the NSPT group. Incidence of Probing Pocket Depth (PPD) ≥ 4 mm reduced significantly in the NSPT + Lumoral® group at both follow-ups (p=0.0019, p=0.0043) but not in the NSPT group. Periodontal epithelial surface area (PESA) and periodontal inflamed surface area (PISA) significantly decreased in the NSPT + Lumoral® group (p<0.01), while no significant changes were observed in the control group.

Conclusion

Regular adjunctive use of Lumoral® after NSPT resulted in improved clinical periodontitis treatment outcomes.

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