Humoral Immunity Against Orthopoxvirus in Vaccinated and Unvaccinated Individuals during 2022 Mpox Outbreak

  1. Yijia Li
  2. Michael B. Townsend
  3. Shanshan Li
  4. Quinn E Testa
  5. Tom Medvec
  6. Elizabeth A. Thompson
  7. Frank J. Palella
  8. Matthew J. Mimiaga
  9. James B. Brock
  10. Maria L. Alcaide
  11. Anandi N. Sheth
  12. Michelle Floris-Moore
  13. Aruna Chandran
  14. Audrey L. French
  15. Phyllis C. Tien
  16. Daniel J Merenstein
  17. Michael Augenbraun
  18. Anjali Sharma
  19. Caitlin A. Moran
  20. Charles R. Rinaldo
  21. Bernard JC. Macatangay
  22. Panayampalli S. Satheshkumar
  23. Ken S. Ho
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Abstract

Little is known about serological responses to MVA-BN (JYNNEOS) against mpox in elderly individuals with or without HIV. In this study, MVA-BN induced sustained IgG levels regardless of HIV status even up to one year. Birth before 1973 correlated with higher IgG. MVA-BN unvaccinated individuals with HIV had lower IgG than vaccinated.

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  1. Version published to 10.1101/2025.03.16.25324075v1 on medRxiv