PIA SSN: Parallel Image Acquisition and Spatial Similarity Network for Tandem Mass Spectrometry Imaging
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Unambiguous molecular annotation in mass spectrometry imaging is essential for understanding complex biochemical processes. Here, we present Parallel Image Acquisition (PIA), for simultaneous imaging with high mass resolution and tandem mass spectrometry, and Spatial Similarity Network (SSN), to annotate isobars and isomers and reveal molecular colocalization. With PIA SSN we uncover phospholipid isomers and isobars in mouse brain tissue and derive cholesterol oxidation metabolites linked to multiple sclerosis.
