Insight into human photoreceptor function: modeling optoretinographic responses to diverse stimuli

Optoretinography is an emerging method for detecting and measuring functional responses from neurons in the living human retina. Its potential applications are significant and broad, spanning clinical assessment of retinal disease, investigation of fundamental scientific questions, and rapid evaluation of experimental therapeutics for blinding retinal diseases. Progress in all these domains hinges on the development of robust methods for quantifying observed responses in relation to visible stimuli. In this work, we describe a novel optoretinographic imaging platform–full-field swept-source optical coherence tomography with adaptive optics, measure cone responses in two healthy volunteers to a variety of stimulus patterns, and propose a simple model for predicting and quantifying responses to those stimuli.