Altered pseudostratified epithelial development of the lateral ventricle choroid plexus in Mllt11 mutants
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The choroid plexuses (ChPs) are modified epithelial structures that penetrate all four cerebral ventricles and secrete cerebrospinal fluid. They consist of a central stroma that is vascularized with fenestrated blood vessels and connective tissue. The ChPs are of dual embryonic origin, with forebrain neuroepithelial cells contributing to the epithelial component and mesenchymal cells contributing to the stromal cells. The growth of the ChPs into the ventricular spaces is fueled by the migration and proliferation of neuroepithelial progenitor cells originating from the cortical hem. However, the genetic regulation of NEP migration during ChP development is not well understood. Here we report the role of Mllt11 (Af1q/Tcf7c) in regulating the formation of the ChP principally by regulating the migration of Otx1/2 + NEPs into the base of the fetal ChP, fueling its growth into the lateral ventricle. We also describe that Mllt11 mutants displayed a loss of the cuboid epithelial architecture of the ChP, altering the pseudostratified epithelial organization of the outer layers of the ChP.
