Structured Gamma Spikes in Mouse Anterodorsal Thalamus
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Gamma-frequency oscillations (∼30–160 Hz) are a hallmark of neuronal syn-chronization, yet the fine-scale temporal arrangement of spikes within individual gamma cycles remains poorly understood. Here, we examine head direction (HD) cells in the mouse anterodorsal thalamic nucleus (ADn)—a circuit distinguished by prominent high-gamma activity—to uncover the principles governing gamma coordination. We reveal two fundamental mechanisms: (i) a stable anatomical gradient in which neurons firing earlier in the gamma cycle exhibit longer anticipatory time intervals (ATIs), and (ii) a dynamic rate-phase shift whereby spike timing advances as the animal’s head aligns with a neuron’s preferred direction. Together, these results delineate a spatiotemporally structured framework for gamma synchronization, advancing our understanding of the functional roles and circuit mechanisms underlying gamma rhythms in local brain networks.
