Real-world brain imaging in a population-based cohort enables accurate markers for dementia
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INTRODUCTION
While a vast amount of MRI data are collected for healthcare delivery, generating real-world evidence (RWE) in Alzheimer’s and related diseases (ADRD) research is substantially limited by lack of methods and results showing how routine MRIs can be used for ADRD imaging studies.
METHODS
We compared three established ADRD biomarkers (total gray matter, hippocampal and ventricular volumes) in four groups (normal, subjective complaints, mild cognitive impairment, and dementia) between the general population of women born in 1932-1941 in the Kuopio region of eastern Finland (population-based OSTPRE cohort, N=14220) and a well-characterized research cohort (ADNI).
RESULTS
A total of 2434 brain MRIs for 1885 women were collected between 2003-2022 by the public healthcare provider covering all residents in the region. The established biomarkers were overall aligned between these cohorts.
DISCUSSION
Typical biomarkers extracted from real-world brain MRI scans collected over 20 years are suitable for generating RWE in ADRD research.
Highlights
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Real-world brain MRI is applicable for generating evidence in ADRD research
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First study comparing a real-world MRI cohort with an established research cohort reference
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A methodological framework for RWE ADRD studies using routinely collected MRIs
