Inspecting Consistency Between US and European Vitamin D Guidelines Using Physiologically-Based Pharmacokinetics Modelling
Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
According to the US official guideline for vitamin D, serum 25-hydroxyvitamin D over 125 nmol/L is linked to potential toxicity. Using a physiologically-based pharmacokinetics model based on a randomised controlled trial in Cape Town, South Africa, we showed the 2000 IU daily dose, recommended by European Food Safety Agency as a safe dose, is expected to lead to serum concentration exceeding the 125 nmol/L threshold among some children and adolescents. This highlights inconsistency between different guidelines and the need to use modelling to bridge the gap between dose and pharmacokinetics.
