A wireless, 60-channel, AI-enabled neurostimulation platform

Electrical stimulation of the human brain has emerged as a powerful therapeutic modality, enabling the alteration of neural circuits underlying cognition and behavior. Recent evidence indicates that stimulation’s effects on physiology and behavior depend on endogenous variation in brain state, as measured by field-potential recordings. Here, we describe a 60-channel brain-computer interface – the Smart Neurostimulation System (SNS) – that combines closed-loop analysis of spectral features of the field potential with multi-channel stimulation capabilities. We demonstrate system functionality via bench tests and from an in vivo ovine study exercising a subset of the device’s functionality. Our ovine study shows that the SNS can reliably measure neural correlates of behavior (motion) and the physiological effects of stimulation. We demonstrate the safety of stimulation via histology following a 120-day stimulation study.