Relative contribution of correcting the diet and voluntary exercise to myocardial recovery in a two-hit murine model of heart failure with preserved ejection fraction
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Most new mouse models of heart failure with preserved ejection fraction (HFpEF) are based on the combination of hypertension and metabolic alterations. These models provide a better approximation of the complexity of the processes involved in human HFpEF. Here, we show that the extent of reverse remodeling and myocardial recovery after stopping the causal stress in a mouse model depends on the biological sex, recovery duration, and diet correction.
