Alpha-Synuclein co-pathology in Alzheimer’s Disease drives tau accumulation
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The molecular basis for accelerated cognitive decline seen in Alzheimer’s Disease (AD) cases presenting with cortical alpha-Synuclein (α-Syn) co-pathology is not well understood. We show that such co-pathology brains express higher levels of microtubule-associated protein tau and that increasing α-Syn expression is sufficient to drive tau accumulation. Our results reveal a hitherto unknown link between the pathogenesis of AD and Parkinson’s Disease whereby tau and α-Syn synergistically drive dementia-related pathology.
