A method for inducing a senescence trend in mesenchymal stem cells using D-galactose 1

  1. Xiaoming Ji
  2. Xiaoyu Zhou
  3. Tingting Chen
  4. Chunchun Duan
  5. Wenjing Tian
  6. Liyang Zhu
  7. Yan Ma
  8. Liyang Gao
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Abstract

The aging of the body is accompanied by a decline in tissue function, and this decline mainly stems from the aging of tissue stem cells. Therefore, they play a crucial role in the aging of the body.This study explores the biological characteristics of senescent hUCMSCs by establishing a replicative senescence model of hUCMSCs and a rapid senescence model induced by D - galactose (D-Gal), and analyzing the proliferative capacity, cell viability, cell cycle, pluripotency, and reactive oxygen species (ROS) levels of senescent hUCMSCs.

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  1. Version published to 10.1101/2025.01.19.633537v1 on bioRxiv