Thalamic involvement defines distinct slow-wave subtypes in NREM sleep

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Abstract

Slow waves (0.5–4 Hz) are a key feature of non-rapid-eye-movement (NREM) sleep, traditionally believed to arise from neocortical circuits. However, growing evidence suggests that subcortical structures, particularly the thalamus, may play a crucial role in initiating and synchronizing slow waves. We tested the hypothesis that slow waves may arise from distinct cortico-cortical and thalamo-cortical mechanisms using simultaneous EEG-fMRI in healthy adults. Spatial mapping based on thalamic fMRI responses revealed two slow-wave associated clusters. Cluster-1 C1, characterized by an early thalamic fMRI-signal increase, corresponded to large, efficiently synchronized waves associated with sleep spindles and with markers of higher arousal and autonomic activation. Cluster-2 C2, marked by an initial negative fMRI response, corresponded to smaller slow waves potentially resulting from cortico-cortical synchronization. These waves tended to more often occur during low-fragility phases of NREM sleep. These findings highlight distinct slow-wave subtypes with different thalamic involvement and, potentially, synchronization mechanisms.

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