Elevated α-synuclein aggregate levels in the urine of patients with isolated REM sleep behavior disorder and Parkinson’s disease
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Parkinson’s disease is a neurodegenerative disorder characterized by α-synuclein aggregation in neurons. Recent advances suggest α-synuclein aggregates could serve as a biomarker for Parkinson’s disease and related synucleinopathies. This study used surface-based fluorescence intensity distribution analysis (sFIDA) to measure α-synuclein aggregates in urine. Patients with Parkinson’s disease and isolated REM sleep behavior disorder, a precursor to Parkinson’s disease, had elevated concentrations compared to healthy controls. Sensitivity and specificity were 83% and 65% for Parkinson’s disease versus controls and 89% and 62% for isolated REM sleep behavior disorder versus controls. The findings highlight sFIDA’s potential for diagnosing synucleinopathies.
