Association between LVEF-1 and Coronary Artery Stenosis and Interventional Treatment Efficacy
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Background
Myocardial ischemia leads to a decrease in the speed and intensity of myocardial tissue contraction. In the early stages, this cardiac dysfunction is difficult to be detected by conventional echocardiography methods.
Objective
First-phase left ventricular ejection fraction (LVEF-1) serves as a sensitive indicator for evaluating myocardial contractility. The aim of this study was to assess the decreased cardiac function caused by myocardial ischemia and its improvement following interventional treatment, as measured by LVEF-1.
Methods
207 patients were enrolled. Based on the results of the angiography, they were categorized into three groups: mild, moderate, and severe. The LVEF-1, Gensini score and other clinical data were compared among these groups. Furthermore, logistic regression analysis was used to analyze the relationship between LVEF-1 and coronary artery stenosis, as well as factors associated with improvement in LVEF-1 following interventional treatment using linear regression.
Results
The LVEF-1 of patients in the 3 groups were 29.6 (28.2, 31.7) %, 27.8 (27.0, 28.6) %, and 25.2 (23.6, 26.5) % (p<0.001). There was a negative relationship between LVEF-1 and the Gensini score (r=-0.694, p<0.001), as well as between LVEF-1 and BNP (r=-0.244, p<0.001). LVEF-1 was identified as an independent predictor for coronary artery stenosis ≥50% or ≥70%. A cutoff value of 26.9% for LVEF-1 had a sensitivity of 89.5% and specificity of 83.9% for predicting the coronary artery stenosis ≥70%. Following intervention, LVEF-1 increased from 24.70 (23.30, 26.32) % to 28.10 (26.80, 29.92) % in 82 patients. Stent diameter was identified as an independent factor influencing the improvement in LVEF-1 post-intervention.
Conclusions
LVEF-1 is negatively correlated with the severity of coronary artery stenosis, and it increases after receiving coronary artery intervention therapy, suggesting that LVEF-1 can serve as a new indicator to evaluate the severity of coronary artery stenosis and the efficacy of interventional treatment.
