Quantification of Brain Functional Connectivity Deviations in Individuals: A Scoping Review of Functional MRI Studies
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Functional connectivity magnetic resonance imaging (fcMRI) is a well-established technique for studying brain networks in both healthy and diseased individuals. However, no fcMRI-based biomarker has yet achieved clinical relevance. To establish better understanding of the state of the art in quantifying abnormal connectivity in comparison to a reference distribution, for potential use in individual patients, we have conducted a scoping review over 5672 entries from the last 10 years. We have located five publications proposing methods of abnormal connectivity quantification, reported these methods and formalized them. We also illustrated the emerging trends and technical innovations in fcMRI research that may facilitate development of individualized fcMRI-based abnormal connectivity metrics.
