The Role of Curcumin Supplementation in Patients with Migraine: A Meta-Analysis of Randomized Controlled Trial
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Objectives
Migraine is a repeated, chronic and neurovascular disease that adversely affects the quality of life and increases the risk of cerebral lesion. Curcumin, the orange-yellow substance of turmeric, may possess anti-headache performance according to several studies. Thus, this study set out to meta-analytically access the anti-headache effect of curcumin supplementation in patients with migraine.
Methods
Five databases were searched as of September 30, 2022 to identify all eligible randomized controlled trials. The random-effect Hunter-Schmidt model was used to calculate the effect sizes based on the heterogeneity. The PROSPERO registration number for this meta-analysis is CRD42023409829 ( https://www.crd.york.ac.uk/PROSPERO/ ).
Results
Four studies involving 170 patients finally met our inclusion criteria. In the results, curcumin supplementation showed a significant difference in the severity of migraine symptoms compared with placebo (Hedges’s g= −0.75, 95% confidence interval (CI) =−1.44 to −0.07, P = 0.03). The results of subgroup analyses indicated that curcumin supplementation was statistically significant in reducing the duration of migraine in patients over 35 years of age (Hedges’s g= −0.63, 95%CI= −1.07 to −0.19, P < 0.01) and high-dose curcumin significantly reduced the severity of migraine symptoms (Hedges’s g= −1.65, 95%CI= −2.32 to −0.97, P < 0.01).
Conclusions
Curcumin supplementation may relieve the severity of headache symptoms in migraine sufferers and appear to be more effective for the headache duration in patients over 35 years of age.
