The aberrant language network dynamics in autism ages 5–40 years
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Background
Language impairments, which affect both structural aspects of language and pragmatic use, are frequently observed in autism spectrum disorder (ASD). These impairments are often associated with atypical brain development and unusual network interaction patterns. However, a neurological framework remains elusive to explain them.
Methods
In this study, we utilized the dynamic "meta-networking" framework of language—a theoretical model that describes the domain-segregation dynamics during resting states—to investigate cortical language network abnormalities in ASD aged 5–40 years.
Results
Our findings revealed distinct developmental trajectories for three domain-specific language subnetworks in ASD, characterized by unique patterns of hypo-and hyper-connectivity that vary with age. Notably, these language network abnormalities proved to be strong predictors of verbal Intelligence Quotient and communication deficits, though they did not predict social abilities or stereotypical behaviors.
Limitations
Due to the limited availability of linguistic data, our study was unable to assess the language deficit profiles of individuals with ASD.
Conclusions
Collectively, these findings refined our understanding of the network mechanisms for language and communication deficits in ASD.
