MEDIAL FRONTAL THETA (MFT) AS A PREDICTOR OF ANXIETY SENSITIVITY TREATMENT RESPONSE

Despite various interventions for anxiety disorders, effects can take months and many individuals do not respond. Activity in the anterior cingulate cortex is a consistent predictor of treatment outcomes, and can be measured by medial frontal theta (MFT) event-related potentials. This study used task-based electroencephalography and MFT to predict anxiety sensitivity treatment response at mid-treatment, 1-week post-treatment, and 6 months post-treatment. Results indicated that lower medial to lateral prefrontal theta phase synchrony was associated with greater symptom improvement. This work represents a novel finding that may contribute to the improvement in treatment efficacy by serving as a target for future interventions and individualized treatment selection.