I answer to clinical scenarios as a real doctor because I “Think”: “ChatGPTo1” new reasoning ability

The adoption of the ChatGPT o1 model represents a significant advancement in the management of clinical cases due to the introduction of a new structured reasoning capability, the “chain-of-thought reasoning” (CoT). In this study, 350 general medicine clinical cases were tested using ChatGPT o1 and ChatGPT o1 mini, and their performance was compared with ChatGPT 4o and ChatGPT 4o mini to evaluate diagnostic accuracy. The results showed that ChatGPT o1 achieved a correct answer rate of 93.4%, outperforming both ChatGPT 4o (82.2%) and the mini versions (ChatGPT o1 mini: 70.2% and ChatGPT 4o mini: 66.2%). The CoT technique enabled the model to provide more coherent and transparent responses, reducing the occurrence of so-called “hallucinations.” This study highlights how the ChatGPT o1 model can be a valuable tool in clinical practice, although its use requires supervision to ensure patient safety, especially in critical settings.