Antiparasitic effect of peptoids against Cryptosporidium parvum

Cryptosporidiosis, caused by Cryptosporidium parvum , poses significant health risks, particularly for children and immunocompromised individuals. Current treatments are ineffective in these vulnerable groups. This study explores the antiparasitic effects of against C. parvum . Out of 14 synthetic peptidomimetics (peptoids) screened, TM9 and TM19 exhibited potent anti-cryptosporidial activity without harming host cells. These findings suggest that peptoids could be a promising new therapeutic avenue for cryptosporidiosis, warranting further investigation.