Blebs regulate phosphoinositide distribution and promote cell survival through the Septin-SH3KBP1-PI3K axis
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We reveal that bleb membranes are enriched in PI(3,4,5)P 3 but depleted in PI(4,5)P 2 compared with non-bleb regions. We find that the Septin-SH3KBP1-PI3K axis establishes differential phosphoinositide distribution, regulates phosphoinositide diffusion, and confers resistance to anoikis in detached tumor cells, providing novel targets to counteract anoikis resistance in cancer.
