Identification of mCMQ069, a novel antimalarial with potential for a single-dose cure and/or 28-day chemoprevention

  1. Anil K. Gupta
  2. James Pedroarena
  3. Armen Nazarian
  4. Jenya Antonova-Koch
  5. Frank Weiss
  6. Krittikorn Kumpornsin
  7. Victor Chi
  8. Ashley K. Woods
  9. Kyoung-Jin Lee
  10. Sean B. Joseph
  11. Shuangwei Li
  12. Jason Brittain
  13. Eugenio De Hostos
  14. James Duffy
  15. Anne Cooper
  16. Peter G. Schultz
  17. Case W. McNamara
  18. Arnab K. Chatterjee
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Abstract

In efforts towards eliminating malaria, a discovery program was initiated to identify a novel antimalarial using KAF156 as a starting point. Following the most recent TCP/TPP guidelines, we have identified mCMQ069 with a predicted single oral dose for treatment (∼40-106 mg) and one-month chemoprevention (∼96-216 mg). We have improved unbound MPC and predicted human clearance by 18-fold and 10-fold respectively when compared to KAF156.

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  1. Version published to 10.1101/2024.07.01.601566v1 on bioRxiv