Theta-burst stimulation over primary somatosensory cortex modulates tactile acuity of tongue

Background

Emerging studies in humans have established the modulatory effects of repetitive transcranial magnetic stimulation (rTMS) over primary somatosensory cortex (S1) on somatosensory cortex activity and perception. However, to date, research in this area has primarily focused on the hand and fingers, leaving a gap in our understanding of the modulatory effects of rTMS on somatosensory perception of the orofacial system and speech articulators.

Objective

The present study aimed to examine the effects of different types of theta-burst stimulation—continuous TBS (cTBS), intermittent TBS (iTBS), or sham—over the tongue representation of left S1 on tactile acuity of the tongue.

Methods

In a repeated-measures design, fifteen volunteers participated in four separate sessions, where cTBS, iTBS, sham, or no stimulation was applied over the tongue representation of left S1. Effects of TBS were measured on both temporal and spatial perceptual acuity of tongue using a custom vibrotactile stimulator.

Results

CTBS significantly impaired spatial amplitude threshold at the time window of 16-30 minutes after stimulation, while iTBS improved it at the same time window. The effect of iTBS, however, was smaller than cTBS. In contrast, neither cTBS nor iTBS had any effect on the temporal discrimination threshold.

Conclusions

The current study establishes the validity of using TBS to modulate somatosensory perception of the orofacial system. Directly modifying somatosensation in the orofacial system has the potential to benefit clinical populations with abnormal tactile acuity, improve our understanding of the role of sensory systems in speech production, and enhance speech motor learning and rehabilitation.

Highlights

• Theta-burst stimulation (TBS) can modulate somatosensation in the orofacial system

• cTBS over S1 impaired spatial acuity of tongue

• iTBS over S1 improved spatial acuity of tongue