FOSL2 Gene Expression Declines with Age in Bone Marrow-derived MSCs

The FOSL2 gene, integral to the AP-1 transcription factor complex, orchestrates cellular responses to stimuli, including immune surveillance and tissue-resident memory T cell differentiation. This study investigates FOSL2's expression dynamics across ages to elucidate its role in aging and age-associated diseases. Leveraging gene expression profiles in response to environmental challenges, we hypothesize that FOSL2 serves as a critical regulator of aging-associated cellular alterations. Utilizing quantitative PCR and RNA sequencing, we charted FOSL2 expression in human bone marrow-derived mesenchymal stromal cells (hMSCs) aged 17-84 years. Statistical analyses reveal a significant negative correlation between FOSL2 expression and age (slope: -0.02442, R-value: -0.41759, P-value: 0.00081), suggesting FOSL2 as a potential biomarker for aging and its involvement in the decline of regenerative capacity. The observed decrease in FOSL2 expression aligns with its role in regulating cellular processes critical in aging. Understanding FOSL2's regulatory network offers insights into aging mechanisms and therapeutic targets for age-related diseases.