Molecular architecture of glideosome and nuclear F-actin in Plasmodium falciparum
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Actin-based motility is required for the transmission of malaria sporozoites. However, direct structural data for this process is lacking. We used FIB-milling and electron cryo-tomography to study untreated actin in situ and dissect the path of actin filaments during parasite gliding. This revealed unexpected structures, including currently unknown filaments reinforcing the pellicle and actin bundles in the nucleus. Implications of these structures for motility and transmission are discussed.
