Tcf21 as a founder transcription factor in specifying Foxd1 cells to the juxtaglomerular cell lineage
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This manuscript provides novel insights into the role of Tcf21 in the differentiation of Foxd1 + cells into JG cells. Using integrated scRNA-seq and scATAC-seq, the study reveals that Tcf21 expression is crucial during early embryonic stages, with its peak at embryonic day 12. The findings demonstrate that inactivation of Tcf21 leads to fewer renin-positive areas and altered renal arterial morphology, underscoring the importance of Tcf21 in the specification of renin-expressing JG cells and kidney development.
