VaccineDesigner: A Web-based Tool for Streamlined Epitope-based Vaccine Design

Epitope-based vaccine design is a promising alternative to conventional methods, focusing on selected antigenic epitopes and molecular fragments that can interact with the immune system and elicit appropriate immune responses. Computational epitope-based vaccine design provides an efficient strategy for immunogenic and safe vaccines; however, the implementation of this approach requires the integration of heterogeneous tools with limited interoperability. VaccineDesigner addresses this issue by offering a user-friendly platform that integrates methods for predicting and evaluating B-cell, CTL, and HTL epitopes. The goal is to provide a Web-based interface for integrated analyses, empowering fast, cost-effective, and rationalized multi-epitope vaccine design in a streamlined process. VaccineDesigner is based on a modular architecture that seamlessly integrates B-cell, CTL, and HTL epitope prediction tools and scoring algorithms, along with multi-epitope vaccine sequence generation. VaccineDesigner is an open-source tool freely available under the academic license at: https://github.com/BiolApps/VaccineDesigner . The Web-based application is accessible at: http://bioinformatics.med.auth.gr/VaccineDesigner