Increased luminal area of large conducting airways in patients with COVID-19 and post-acute sequelae of COVID-19: a retrospective case-control study

  1. Solomiia Zaremba
  2. Alex J. Miller
  3. Erik A. Ovrom
  4. Jonathon W. Senefeld
  5. Chad C. Wiggins
  6. Paolo B. Dominelli
  7. Ravindra Ganesh
  8. Ryan T. Hurt
  9. Brian J. Bartholmai
  10. Brian T. Welch
  11. Juan G. Ripoll
  12. Michael J. Joyner
  13. Andrew H. Ramsook
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Abstract

Three-dimensional reconstruction of airways has shown increased luminal area in patients with COVID-19 and post-acute sequelae of COVID-19 when compared with healthy controls. These findings suggest the role of large conducting airways in the pathogenesis of post-acute sequelae of COVID 19.

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  1. Version published to 10.1152/japplphysiol.00573.2024
  2. Version published to 10.1101/2024.02.29.24303556 on medRxiv