An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)

  1. Lai Wei
  2. Shuiqing Liu
  3. Shanshan Lu
  4. Shengdong Luo
  5. Xiaoping An
  6. Huahao Fan
  7. Weiwei Chen
  8. Erguang Li
  9. Yigang Tong
  10. Lihua Song

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Abstract

SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) is highly attenuated, but can cause mortality in a specifically designed human ACE2-transgenic mouse model, making it an invaluable surrogate model for evaluating the efficacy of drugs and vaccines against SARS-CoV-2.

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  1. Rapid Reviews Infectious Diseases

    Alex Crits-Christoph

    Review 1: "An Infection and Pathogenesis Mouse Model of SARS-CoV-2-related Pangolin Coronavirus GX_P2V(SHORT_3UTR)"

    Overall, the reviewer suggested the mouse model to be a poor representative of real animal or human pathology.

  3. Version published to 10.1101/2024.01.03.574008v2 on bioRxiv
  4. Version published to 10.1101/2024.01.03.574008v1 on bioRxiv