Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity

  1. Alberto Moreno
  2. Kelly Manning
  3. Maryam I. Azeem
  4. Ajay K. Nooka
  5. Madison Ellis
  6. Renee Julia Manalo
  7. Jeffrey M. Switchenko
  8. Bushra Wali
  9. Jonathan L. Kaufman
  10. Craig C. Hofmeister
  11. Nisha S. Joseph
  12. Sagar Lonial
  13. Kavita M. Dhodapkar
  14. Madhav V. Dhodapkar
  15. Mehul S. Suthar
Read the full article See related articles

Listed in

This article is not in any list yet, why not save it to one of your lists.
Log in to save this article

Abstract

We characterized virus-neutralization and spike-binding antibody profiles in myeloma patients following monovalent or bivalent-SARS-CoV-2 booster vaccination. Vaccination improves the breadth of binding antibodies but not neutralization activity against current variants. Hybrid immunity and immune imprinting impact vaccine-elicited immunity.

Article activity feed

  1. Version published to 10.1101/2023.08.17.553767v1 on bioRxiv