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  1. SciScore for 10.1101/2022.06.02.22275894: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    NIH rigor criteria are not applicable to paper type.

    Table 2: Resources

    For the enzyme-linked immunosorbent assays (ELISA) for the detection of IgG antibodies against the S1 domain of the SARS-CoV-2 spike (S) protein in serum (Anti-SARS-CoV-2-ELISA (IgG)
    Anti-SARS-CoV-2-ELISA (IgG
    suggested: None
    y) detecting human immunoglobulins, including IgG, IgA and IgM against the spike receptor binding (RBD) domain protein, samples with ≥ 264 U/ml were considered to be positive as recommended by Caillard et al.8,9 Any non-zero antibody level below this cutoff was considered low positive (with limit of detection being 0.4 U/mL).
    IgM against the spike receptor binding (RBD) domain protein
    suggested: None
    Outcome and Predictors: The single outcome variable was a positive serological response defined by the maximum anti-SARS-CoV-2 spike (S) IgG or antibody level after a minimum of 14 days following the date of vaccination and before any further immunization event such as SARS-CoV-2 infection, passive or active immunization.
    anti-SARS-CoV-2 spike (S) IgG
    suggested: (Leinco Technologies Cat# S540, RRID:AB_2831778)
    Generally, IgG or antibody positivity was determined based on local laboratory’s pre-defined positivity cutoff, which was mostly the one provided by the manufacturer.
    suggested: None
    For each validation set, we excluded vaccinations with missing SARS-CoV-2 IgG data, missing information about the SARS-CoV-2 spike IgG or antibody assay used, missing medication data, or missing eGFR, lymphocyte count, or hemoglobin level.
    SARS-CoV-2 spike IgG
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

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