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  1. SciScore for 10.1101/2022.05.04.22274208: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: The Research Ethics Board at Sunnybrook Health Sciences Centre approved this study.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    MRI processing: MRI processing was performed using tools from the FMRIB Software Library (FSL, version 6.0.3).
    suggested: (FSL, RRID:SCR_002823)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    These results need to be interpreted in the context of several limitations. First, although well-matched, the sample sizes of the two groups were modest and unequal; furthermore, a power analysis was not performed. To our knowledge, the current study benefits from the largest ASL dataset focusing on non-hospitalized adults in the post-COVID-19 timeframe. Moreover, recruitment for the NeuroCOVID-19 study is on-going and will address these issues in future studies. Second, our recruitment may be confounded by selection bias. For example, the current study’s cohort was comprised of 66% female and 72% Caucasian participants. We further note that participants needed internet access to be screened for eligibility. Third, our control group exhibited flu-like symptoms of unknown origin. The recruitment of this unique control group is a relatively novel aspect of this study, as these participants are a de-novo sample of adults that experienced non-specific flu-like symptoms during the pandemic. Fourth, ASL images were acquired at a spatial resolution comparable to the average thickness of the cortex, which may be susceptible to partial volume error.45 To address this, we included partial volume correction as an additional ASL processing step in a sensitivity analysis, which did not drastically change the results. Fifth, our fatigue-related exploratory analysis relied on self-reported symptoms. Study staff ensured that on-going fatigue was understood as being impairing to activities of...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

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