SARS-CoV-2 infections in infants in Haiti 2020–2021; evidence from a seroepidemiological cohort
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Abstract
Few data are available on frequency of SARS-CoV-2 infection among very young children in low- to middle-income countries (LMIC), with the studies that are available biased towards higher income countries with low reported infection and seroconversion rates. Between February 2019 and March 2021, 388 dried blood spot (DBS) samples were obtained from 257 children less than 30 months of age as part of a prospective observational cohort study of pregnant women and their infants in Haiti; longitudinal samples were available for 107 children. In a subsequent retrospective analysis, DBS samples were tested by ELISA for antibody targeting the receptor binding domain of the SARS-CoV-2 S1 protein. Over the course of the study, 16·7% of the infants became seropositive. All seropositive samples were collected after March 19, 2020 (the date of the first reported COVID-19 case in Haiti) with the highest hazards measured in August 2020. Sampling date was the only covariate associated with the hazard of seroconversion. Our data provide an estimate of SARS-CoV-2 infection rates among very young children without prior SARS-CoV-2 exposure during the initial pandemic waves in Haiti, and demonstrate that these children mount a detectable serological response which is independent of patient age.
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SciScore for 10.1101/2022.03.17.22272561: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Field Sample Permit: This study was conducted under review of the University of Florida (UF) IRB and the Haitian Comite National de Bioethique of the Ministere De La Sante Publique Et De La Population. Sex as a biological variable Many mothers were also hesitant about allowing a heel-stick for blood collection. Randomization not detected. Blinding not detected. Power Analysis We estimated that with 50 samples collected before the pandemic and 50 after, we had 80% power to detect a difference in seroprevalence assuming 15% of babies would be seropositive after the beginning of the pandemic and 0% before (with 95% confidence). Table 2: Resources
No key resources detected.
Results from OddPub: We did …
SciScore for 10.1101/2022.03.17.22272561: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Field Sample Permit: This study was conducted under review of the University of Florida (UF) IRB and the Haitian Comite National de Bioethique of the Ministere De La Sante Publique Et De La Population. Sex as a biological variable Many mothers were also hesitant about allowing a heel-stick for blood collection. Randomization not detected. Blinding not detected. Power Analysis We estimated that with 50 samples collected before the pandemic and 50 after, we had 80% power to detect a difference in seroprevalence assuming 15% of babies would be seropositive after the beginning of the pandemic and 0% before (with 95% confidence). Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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