Effectiveness of Covid-19 vaccines against symptomatic and asymptomatic SARS-CoV-2 infections in an urgent care setting
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SciScore for 10.1101/2022.02.21.22271298: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: This study was approved by the Institutional Review Board of the City University of New York.
Consent: Patient consent was not obtained because deidentified electronic health records were used.
Field Sample Permit: SARS-CoV-2 infection - Cases and Controls: Testing for SARS-CoV-2 conducted at CityMD using assays authorized by the Food and Drug Administration (FDA), included: PCR tests of respiratory tract specimens for SARS-CoV-2 RNA collected via nasopharyngeal and nasal swabs and rapid antigen tests of respiratory tract specimens collected via anterior nasal swabs.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table …
SciScore for 10.1101/2022.02.21.22271298: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: This study was approved by the Institutional Review Board of the City University of New York.
Consent: Patient consent was not obtained because deidentified electronic health records were used.
Field Sample Permit: SARS-CoV-2 infection - Cases and Controls: Testing for SARS-CoV-2 conducted at CityMD using assays authorized by the Food and Drug Administration (FDA), included: PCR tests of respiratory tract specimens for SARS-CoV-2 RNA collected via nasopharyngeal and nasal swabs and rapid antigen tests of respiratory tract specimens collected via anterior nasal swabs.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has limitations. Even though test-negative design controls for bias due to healthcare-seeking behavior and access, the rates of testing between vaccinated and unvaccinated people might differ. Vaccinated individuals with symptoms could be more motivated to get tested which would lead to an overrepresentation of vaccinated individuals with positive test results, biasing the VE estimates downwards 64. Bias due to unmeasured confounders, such as occupation or behavior changes following policies or vaccination is also possible 65,66. We may have missed reports of prior infections if participants were tested at other clinics, which could also bias VE estimates downwards. Outcomes for patients who received only an antigen test could be misclassified due to lower test sensitivity. However, our sensitivity analysis showed that when restricted to the highly sensitive RT-PCR tests results, VE estimates were nearly identical to those of the overall sample. Misclassification of exposure is a possibility as vaccination status was self-reported and dates of vaccination were not collected. However, other studies have shown very high agreement between self-reported and recorded COVID-19 vaccination status 67,68. VE after one dose of mRNA vaccines is likely underestimated in this study because it was not known if the outcome occurred more than 15 days after the first dose. We did not collect information on disease severity and hospitalization and could not differentiate between asym...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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