Endogenous pancreatic microRNAs differentially target the Delta, Omicron, and Wuhan SARS-CoV-2 genomes to upregulate the Diabetes-associated genes
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Abstract
The SARS-CoV-2 viral genome is mutating and evolving into new variations, including the recently discovered Delta and Omicron. In this study, we used and evaluated our notion of differential targeting of SARS-CoV-2 variant genomes by microRNAs (miRNAs) of the infected human pancreas. We found that even with UTR mutations, the Delta, Omicron, and original Wuhan variations’ genomes would be differentially targeted by the host pancreas cell’s native miRNAs in the same way. The miRNAs show a difference in Minimal Free Energy (MFE) with the different viral variants’ genomes; however, they would still be responsible for the upregulation of the diabetes-associated genes.
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SciScore for 10.1101/2022.01.26.477612: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources MFE analysis of miRNAs targeting the UTR sequences of SARS-CoV-2 variants’ genomes: The miRNAs targeting the UTR sequences of the Delta and Omicron strain genomes were obtained by using the miRDB online tool [7, 8]. miRDBsuggested: (miRDB, RRID:SCR_010848)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques …SciScore for 10.1101/2022.01.26.477612: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources MFE analysis of miRNAs targeting the UTR sequences of SARS-CoV-2 variants’ genomes: The miRNAs targeting the UTR sequences of the Delta and Omicron strain genomes were obtained by using the miRDB online tool [7, 8]. miRDBsuggested: (miRDB, RRID:SCR_010848)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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