PRICE COVID19 Data Report December 2021 Pakistan Registry of Intensive Care

  1. Ahmed farooq
  2. Rahatullah Arsalan
  3. Mufti Kulsoom Aisha
  4. Asim Muhammad
  5. Muhammad Hayat
  6. Aneela Altaf
  7. Arshad Taqi
  8. Ashok Kumar
  9. Attaur Rehman
  10. Fakhir Raza Haidri
  11. Iqbal Hussain
  12. Mobin Chaudhry
  13. Safdar Rehman
  14. Irfan Malik
  15. Jodat Saleem
  16. Liaquat Ali
  17. Muhammad Ashraf Zia
  18. Maria Ali Khan
  19. Mohiuddin Sheikh
  20. Muhammad Sheharyar Ashraf
  21. Muhammad Asim Rana
  22. Muhammad Nasir Khoso
  23. Saadiya Rizvi
  24. Naseem Ali Shaikh
  25. Nawal Salahuddin
  26. Qurat-ul-Ain Khan
  27. Rana Imran Sikander
  28. Syed Muneeb Ali
  29. Rashid Nasim Khan
  30. Sairah Babar
  31. Abigail Beane
  32. Arjen M Dondorp
  33. Chamira Kodippily
  34. Dilanthi Priyadarshani
  35. Ishara Udayanga
  36. Pramodya Ishani
  37. Sri Darshana
  38. Thalha Rashan
  39. Rashan Haniffa
  40. Srinivas Murthy
  41. Madiha Hashmi

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Abstract

Abstract Pakistan Registry of Intensive Care (PRICE) is a platform that has enabled standardized COVID-19 clinical data collection based on ISARIC/WHO Clinical Characterization Protocol. The near real-time data platform includes epidemiology, severity of illness, microbiology, treatment and outcomes of patients admitted with suspected or laboratory confirmed COVID19 infection to 67 intensive care and high dependency units across the country. Data has been extracted and analysed at regular intervals to inform stakeholders and improve care practices. This is our 28th report including all patients with suspected or confirmed COVID-19 from 26th March 2020 to 26th December 2021. Key findings from 8624 patients who met eligibility criteria, are as follows: ● Median age of 60 years (IQR 50-70). ● The most common symptoms were shortness of breath (n = 6428, 77.8%), fever (n = 6091, 73.8%), and Cough (n = 3354, 38.9%) ● The most common comorbidity was hypertension followed by diabetes. ● During the course of illness 2804 (32.6%) patients received non-invasive ventilation, whereas 2474 (28.8%) patients had mechanical ventilation as their highest organ support. In addition, 2246 (26.1%) patients needed haemodynamic support and 1249 (14.7%) patients required renal replacement therapy as their highest organ support. ● Median APACHE II score was 18 ● Overall mortality at ICU discharge was 39.2% ● Increasing age and requirement for invasive mechanical ventilation were independent risk factors for mortality increased the risk of death

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    SciScore for 10.1101/2022.01.20.22269202: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Ethicsnot detected.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    The same PRICE platform was adapted to incorporate ISARIC/WHO Clinical Characterization Protocol (CCP) tiers 0-3 capturing clinical and epidemiological data of patients admitted to the collaborating high dependency (HDU) and intensive care units (ICU) with clinically suspected or laboratory confirmed COVID19 infection (9).
    PRICE
    suggested: (PRICE, RRID:SCR_013063)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

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  2. Version published to 10.1101/2022.01.20.22269202v1 on medRxiv