1. SciScore for 10.1101/2022.01.13.22269178: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Ethicsnot detected.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    Data were stored in REDCap (Research Electronic Data Capture, Vanderbilt University, Nashville, TN).
    suggested: (REDCap, RRID:SCR_003445)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Our study is subject to limitations. First, like all observational SARS-CoV-2 studies, we could not implement routine universal SARS-CoV-2 screening to identify all patients with SARS-CoV-2 infection. This limitation is problematic especially for prognostic analyses, because of uncertainty regarding the proportion of included patients being asymptomatic at diagnosis and their COVID-related symptom burden at the time of diagnosis. The observation that median days to hospitalization after estimated date of infection did not differ significantly by HIV status provides some support that trajectories of disease progression were similar for both groups. Second, to reduce bias in our analyses due to missing records, varying standards of care, and referral indication, individuals were excluded if part of the COVID-19 care cascade occurred outside of UCSD Health. The number of excluded patients is unlikely to alter the conclusions based on included patients. Third, conclusions regarding the effect of HIV infection on ICU admission and hospital mortality should be interpreted cautiously because of the small number of ICU and mortality events in the study sample. Fourth, our PWH cohort generally had well-controlled HIV infection, with only 7% of those tested having AIDS and 9% a pVL above 200 copies/mL (Supplementary Table 4). Hence, our findings cannot be generalized to PWH populations with higher proportions of unsuppressed viremia. Similarly, we did not assess nadir CD4 counts, which...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

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