The impact of the COVID-19 pandemic on cardiovascular disease prevention and management
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Abstract
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SciScore for 10.1101/2021.12.31.21268587: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Field Sample Permit: For stratified and incident analyses medication records were required to have a valid pseudo-identifier ID (a non-identifying unique master key that replaces the NHS number following linkage) for data linkage to socio-demographic and regional characteristics. Sex as a biological variable We included medications dispensed to individuals who were aged between 18 and 112 years, with sex reported as male or female and at pharmacies in the relevant nation (for example, in England Lower-layer Super Output Area (LSOA) starting with E). Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank …
SciScore for 10.1101/2021.12.31.21268587: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Field Sample Permit: For stratified and incident analyses medication records were required to have a valid pseudo-identifier ID (a non-identifying unique master key that replaces the NHS number following linkage) for data linkage to socio-demographic and regional characteristics. Sex as a biological variable We included medications dispensed to individuals who were aged between 18 and 112 years, with sex reported as male or female and at pharmacies in the relevant nation (for example, in England Lower-layer Super Output Area (LSOA) starting with E). Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Strengths and weaknesses of the study: This is the largest ever study to date using a medicines lens to investigate the impact of the COVID-19 pandemic on CVD risk factors at a population-scale in England, Scotland and Wales. A strength of using a medicines perspective is that it is closer to the active control of CVD risk factors in the patient population. We developed and applied a new categorisation of CVD medicines according to prescribed medicine use for this purpose informed by pharmacological and clinical knowledge of use of these medicines in practice. A limitation relates to the difficulty in assigning diseases for overlapping indications for some medications. The approach we used aligns with the primary indication for a medication as per the BNF. This may result in underestimates of certain CVDs. For example, heart failure is likely to be underestimated as management options overlap with hypertension and type-2 diabetes (e.g. ACE-I, beta blockers and SGLT-2 inhibitors). This analysis could be extended in future work by linking to disease diganosis codes to refine estimates for heart failure. However, the analyses presented here do give an indication of the overall missed CVD risk factors to alert policy makers to the indirect effect of COVID-19. These analyses do not take account of dispensed quantity with each dispense counting as a single unit and this issue lends itself to further research. We used atorvastatin 40mg and simvastatin 40mg to demonstrate that this i...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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