Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19

  1. George R. Abraham
  2. Rhoda E. Kuc
  3. Magnus Althage
  4. Peter J. Greasley
  5. Philip Ambery
  6. Janet J. Maguire
  7. Ian B. Wilkinson
  8. Stephen P. Hoole
  9. Joseph Cheriyan
  10. Anthony P. Davenport

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Abstract

No abstract available

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  1. Version published to 10.1016/j.yjmcc.2022.03.007
  2. ScreenIT

    SciScore for 10.1101/2021.12.30.21268236: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsConsent: Plasma samples and clinical variables were obtained with ethical approval (REC:17/EE/0025) and informed consent from participants enrolled in the Cambridge NIHR Covid-19 Biobank project.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Statistical analysis was performed using SPSS version 27 (IBM Corp., USA) for Windows.
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Limitations: Our study is limited by its retrospective observational design with all patients enrolled during the first wave of the pandemic, when no specific therapies for Covid-19 were known and prior to the availability of vaccines. Further exploration of the pathophysiological changes resulting from elevated ET-1 levels in critically unwell patients was not feasible in this period.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.12.30.21268236v1 on medRxiv