Evaluation of the Implementation of the 4C Mortality Score in United Kingdom hospitals during the second pandemic wave

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1. 

   Version published to 10.1101/2021.12.18.21268003v2 on medRxiv

   Jan 4, 2022
2. 

   ScreenIT

   Dec 30, 2021

   SciScore for 10.1101/2021.12.18.21268003: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	IRB: This study was classified as service evaluation by the West of Scotland Research Ethics Committee.
   Sex as a biological variable	not detected.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   Data were collected on a REDCap database (Research Electronic Data Capture, Vanderbilt University, US) (6).	REDCap suggested: (REDCap, RRID:SCR_003445)

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   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

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   Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

   The …

   SciScore for 10.1101/2021.12.18.21268003: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	IRB: This study was classified as service evaluation by the West of Scotland Research Ethics Committee.
   Sex as a biological variable	not detected.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   Data were collected on a REDCap database (Research Electronic Data Capture, Vanderbilt University, US) (6).	REDCap suggested: (REDCap, RRID:SCR_003445)

   ---

   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

   ---

   Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

   The 4C Score was chiefly used to inform treatment escalation, but was also used to inform decisions on patient destination (i.e. discharge or admission location) as well as treatment limitation. Although half of participating sites incorporated the 4C Score within guidance, documentation of the score varied substantially between sites. Audits of documentation of established mortality risk scores such as CURB-65 (for patients with community-acquired pneumonia) have also demonstrated variable recording (8,9). Nevertheless, our findings suggest that documentation of the 4C Score may be encouraged by incorporation into clinicians’ workflow through admissions proformas, detailing 4C Score variables or online calculator within guidance, in addition to linking the score to management recommendations. This project demonstrates the capacity of national trainee networks to facilitate multi-centre studies. Collaboration with NITCAR and other trainee networks enabled the rapid recruitment of 41 UK sites and completion of >4,000 case note reviews within a short timeframe. This study has several limitations. Although NITCAR is a national organisation, site participation was not representative, with a preponderance towards Scottish sites and no sites included from Wales or Northern Ireland. We assumed that guidance documents reported by sites between June and September 2021 were in use in January 2021 (period selected for retrospective case note review); some of these documents may not have...

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   Results from TrialIdentifier: No clinical trial numbers were referenced.

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   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

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   Results from JetFighter: We did not find any issues relating to colormaps.

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   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
   • No protocol registration statement was detected.

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   Results from scite Reference Check: We found no unreliable references.

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   Read the original source
3. 

   Version published to 10.1101/2021.12.18.21268003v1 on medRxiv

   Dec 19, 2021