Potential cross-protection against SARS-CoV-2 from previous exposure to bovine coronavirus
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Abstract
Humans have long shared infectious agents with cattle, and the common cold OC-43 CoV is a not-so-distant example of cross-species viral spillover. Human exposure to BCoV is certainly common, as the virus is endemic in cattle-raising regions. This article shows an in silico investigation of shared viral epitopes between BCoV and SARS-CoV-2. HLA recognition and lymphocyte reactivity were assessed using freely-available resources. Several epitopes were shared between BCoV and SARS-CoV-2, both for B and T lymphocytes. These data demonstrate that possible cross-protection is being induced by human exposure to cattle.
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SciScore for 10.1101/2021.12.13.472476: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources 2.1 Setting-up the peptides for analysis: The proteome sequences of bovine coronavirus were obtained from the NCBI database and focused on four proteins (Table 1): spike protein, membrane protein, nucleocapsid protein and replicase polyprotein (Orf1ab). NCBIsuggested: (NCBI, RRID:SCR_006472)2.4 Identity of bovine peptides with human SARS-CoV-2 proteins: All bovine peptides that were above the threshold for T cells and B cells were analyzed for identity to the corresponding proteins of human SARS-CoV-2 (Table … SciScore for 10.1101/2021.12.13.472476: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources 2.1 Setting-up the peptides for analysis: The proteome sequences of bovine coronavirus were obtained from the NCBI database and focused on four proteins (Table 1): spike protein, membrane protein, nucleocapsid protein and replicase polyprotein (Orf1ab). NCBIsuggested: (NCBI, RRID:SCR_006472)2.4 Identity of bovine peptides with human SARS-CoV-2 proteins: All bovine peptides that were above the threshold for T cells and B cells were analyzed for identity to the corresponding proteins of human SARS-CoV-2 (Table 1) using the Multiple Sequence Alignment (Clustal Omega, Clustal Omegasuggested: (Clustal Omega, RRID:SCR_001591)GraphPad Prism 8 (GraphPad Software, Inc., USA) was used for graphing and for statistical analysis. GraphPadsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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