Plasma Neutralization of the SARS-CoV-2 Omicron Variant
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SciScore for 10.1101/2021.12.12.21267646: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization Plasma samples were collected approximately 1, 5-6 and 12 months after initial vaccination or infection and selected for this study at random with respect to binding, neutralization titer, or donor demographic characteristics. Blinding not detected. Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Antibodies Sentences Resources The study visits and blood draws were reviewed and approved by the Institutional Review Board of the Rockefeller University (IRB no. DRO-1006, ‘Peripheral Blood of Coronavirus Survivors to Identify Virus-Neutralizing Antibodies’). Antibodies’suggested: None… SciScore for 10.1101/2021.12.12.21267646: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization Plasma samples were collected approximately 1, 5-6 and 12 months after initial vaccination or infection and selected for this study at random with respect to binding, neutralization titer, or donor demographic characteristics. Blinding not detected. Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Antibodies Sentences Resources The study visits and blood draws were reviewed and approved by the Institutional Review Board of the Rockefeller University (IRB no. DRO-1006, ‘Peripheral Blood of Coronavirus Survivors to Identify Virus-Neutralizing Antibodies’). Antibodies’suggested: NoneExperimental Models: Cell Lines Sentences Resources The pseudotyped virus and antibody mixture was transferred to 96 well plates containing HT1080/ACE2.cl14 cells. HT1080/ACE2.cl14suggested: NoneRecombinant DNA Sentences Resources These synthetic DNA fragments, ranging in size from 444-599bp and a NheI/XbaI-linearized pCR3.1 plasmid were Gibson assembled via 40bps overlapping sequences. pCR3.1suggested: RRID:Addgene_106457)Software and Algorithms Sentences Resources The half-maximal plasma neutralizing titer (NT50) was determined using four-parameter nonlinear regression (least squares regression method without weighting) (GraphPad Prism). GraphPadsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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