SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals

  1. Kaori Sano
  2. Disha Bhavsar
  3. Gagandeep Singh
  4. Daniel Floda
  5. Komal Srivastava
  6. Charles Gleason
  7. PARIS Study Group
  8. Angela A. Amoako
  9. Dalles Andre
  10. Katherine F. Beach
  11. Maria C. Bermúdez-González
  12. Gianna Cai
  13. Christian Cognigni
  14. Hisaaki Kawabata
  15. Giulio Kleiner
  16. Neko Lyttle
  17. Wanni Mendez
  18. Lubbertus C. F. Mulder
  19. Annika Oostenink
  20. Ariel Raskin
  21. Aria Rooker
  22. Kayla T. Russo
  23. Ashley Beathrese T. Salimbangon
  24. Miti Saksena
  25. Levy A. Sominsky
  26. Johnstone Tcheou
  27. Ania Wajnberg
  28. Juan Manuel Carreño
  29. Viviana Simon
  30. Florian Krammer

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Abstract

Immune responses at the respiratory mucosal interface are critical to prevent respiratory infections but it is unclear to what extent antigen specific mucosal secretory IgA (SIgA) antibodies are induced by mRNA vaccination in humans. Here we analyze paired serum and saliva samples from patients with and without prior coronavirus disease 2019 (COVID-19) at multiple time points pre and post severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. Our results suggest mucosal SIgA responses induced by mRNA vaccination are impacted by pre-existing immunity. Indeed, vaccination induced a minimal mucosal SIgA response in individuals without pre-exposure to SARS-CoV-2 while SIgA induction after vaccination was more efficient in patients with a history of COVID-19.

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  1. Version published to 10.1038/s41467-022-32389-8
  2. ScreenIT

    SciScore for 10.1101/2021.12.06.21267352: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Ethicsnot detected.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a protocol registration statement.

    Results from scite Reference Check: We found no unreliable references.

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  3. Version published to 10.1101/2021.12.06.21267352v1 on medRxiv