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  1. SciScore for 10.1101/2021.11.30.21267048: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: Ethics: The DGPI registry was approved by the Ethics Committee of the Technische Universität (TU) Dresden (BO-EK-110032020) and was assigned clinical trial number DRKS00021506.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    The SARS-CoV-2 KIDS study authors reported a seroprevalence of SARS-CoV-2 IgG antibodies of 10.8% (95% CI 8.7, 12.9) for March 2021, and observed no major change through May 2021 [8].
    SARS-CoV-2 IgG
    suggested: None
    Software and Algorithms
    REDCap is a secure, web-based software platform designed to support data capture for research studies, providing 1) an intuitive interface for validated data capture; 2) audit trails for tracking data manipulation and export procedures; 3) automated export procedures for seamless data downloads to common statistical packages; and 4) procedures for data integration and interoperability with external sources.
    suggested: (REDCap, RRID:SCR_003445)
    Our analysis was performed using SAS Version 9.4 (SAS Institute, Cary, NC, USA).
    SAS Institute
    suggested: (Statistical Analysis System, RRID:SCR_008567)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Strengths and limitations: The strength of our analysis lies in its provision of reliable estimates for evaluating the risk of severe manifestations related to SARS-CoV-2 infections in children. Our analysis has several limitations, mainly due to uncertainties in the raw data in the three different sources, which are mostly estimates. The population at risk: We do not know the exact number of SARS-CoV-2 infections in children in Germany. We have estimated the number based upon recently published results of a nationwide, prospective survey of IgG antibodies in pediatric patients in German pediatric hospitals. Limitations include potential selection bias, ELISA cut-off values, precision and the suitability of IgG detected by ELISA to depict SARS-CoV-2 infections in children. Nevertheless, the data are comparable to the standards of other seroprevalence estimates worldwide. On this basis, our data provide the best available estimates for Germany. The number of cases: Reporting to the DGPI register is voluntary, while reporting laboratory-confirmed SARS-CoV-2 infections to the statutory notification system is compulsory. Thus, the latter may be assumed to be more comprehensive. Because case definitions in the DGPI register and the statutory notification system were identical, this provides a reasonable basis for correcting the underreporting of the DGPI cases based upon the statutory notification system. Limiting the analysis to children up to the age of 14 (rather than 17) is a ...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

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