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  1. SciScore for 10.1101/2021.11.29.21266777: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: This project was approved by the Stanford University Institutional Review Board (Protocol ID 47191, “Public Health Surveillance in the Department of Veterans Affairs”) and written informed consent was waived.
    Consent: This project was approved by the Stanford University Institutional Review Board (Protocol ID 47191, “Public Health Surveillance in the Department of Veterans Affairs”) and written informed consent was waived.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Our findings are subject to several limitations. Clinical records for patients who received care in facilities external to VHA might not be available in VHA databases unless these services were ordered by VHA providers and paid for by VHA; therefore, these testing episodes and outcomes would be missed in our analysis. Although VHA issued national testing guidelines, differences across VHA facilities in testing assays and local policies or approaches to testing may contribute to variability in detection of vaccine breakthrough events; some events might have been missed or misclassified. Our study population consists of predominantly older, male persons; therefore, our results might not be generalizable to the larger US population. Though we sought to control for health-seeking behavior as well as demographic and clinical covariates associated with COVID-19, unmeasured confounders might affect our findings. To reduce residual confounding, we excluded long term care residents; our findings might not be applicable to this subgroup. Though we observed modest effectiveness of a third dose of vaccine in reducing post-vaccination infection, we were unable to assess associations with broader epidemiological outcomes such as reduced transmission among contacts. Given the observational nature of this study, data describing additional biomarkers, timing of exposures, symptoms, and the specific variants occurring in vaccine breakthrough events were unavailable; therefore, we were unable t...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • No funding statement was detected.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.


    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

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