Immune Response to COVID-19 in India through Vaccination and Natural Infection

  1. Tresa Rani Sarraf
  2. Shreyasi Maity
  3. Arjun Ghosh
  4. Suchandan Bhattacharjee
  5. Arijit Pani
  6. Kaushik Saha
  7. Dhrubajyoti Chattopadhyay
  8. Gourisankar Ghosh
  9. Malini Sen

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Abstract

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  1. Version published to 10.26502/fjhs.070
  2. ScreenIT

    SciScore for 10.1101/2021.11.08.21266055: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: & Ethical Declaration: An Institutional Review Board (IRB) on Human Subjects was constituted following the guidelines of the Indian Council for Medical Research (ICMR).
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    The secondary antibody (anti mouse IgG/IgM/IgA-HRP conjugated, Sigma, USA) in a 1:5000 dilution was then added to each well and incubation was done at room temperature for 45 minutes.
    anti mouse IgG/IgM/IgA-HRP
    suggested: None
    Since human ACE-2 is tagged with mouse Fc for its binding to anti-mouse secondary antibody, the secondary antibody (anti mouse IgG-HRP conjugated, Sigma USA) was added in 1:5000 dilution to the wells.
    anti-mouse
    suggested: None
    anti mouse IgG-HRP
    suggested: None
    Software and Algorithms
    SentencesResources
    Samples were analyzed by distribution plot with Graph Pad Prism version 8.3.1 software.
    Graph Pad Prism
    suggested: (GraphPad Prism, RRID:SCR_002798)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a protocol registration statement.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.11.08.21266055 on medRxiv